Immune Health

Immune Health
Understanding Immune Health

At the core of human health lies our immune system, maintaining vital balance throughout our bodies. Yet, despite its critical importance, immune health has remained an underappreciated frontier in modern medicine, leaving many vulnerable to infections and chronic diseases.

 

Today, we stand at a crossroads. Our increasingly urban, sanitized environments disrupt microbial exposures that are key for the development of our immune system.1,2 Antimicrobial resistance threatens our ability to treat common infections.3 Recurrent infections compromise health and quality of life for millions worldwide.4-7

 

It's time to reimagine our approach to immune health — one that addresses the root causes of vulnerable immune function rather than simply responding to illness after it occurs.

What Is Immune Health?

Immune health isn't simply about boosting immunity — it's about achieving balance.
A properly functioning immune system must be:

immune health Responsive enough to combat pathogens effectively

Responsive enough to combat pathogens effectively

immune health Regulated to prevent excessive and inappropriate activity

Regulated to prevent excessive and inappropriate activity

immune health Resilient to repeated challenges

Resilient to repeated challenges

immune health Adaptable to evolving threats

Adaptable to evolving threats

This delicate balance forms the foundation of health, allowing our immune system to regulate and adapt to changing circumstances, protecting us throughout our lives.

IMMUNE HEALTH DEFINITION

“The ability to effectively combat infections while maintaining tolerance to environmental triggers and preventing excessive inflammation that could cause tissue damage or autoimmunity.”

- Imm'Uni™ Steering Committee
Factors Affecting Human Health and Their Consequences

Our immune system balance can be influenced at any time by various factors. 

immune health environmental factors
ENVIRONMENTAL FACTORS
Immune Health air pollution
Air Pollution

triggers oxidative stress and weakens immune responses, including frontline defenses, increasing susceptibility to respiratory infections.10,11

Immune Health Diverse microbial exposure
Diverse microbial Exposure

in early life is crucial for proper immune system development. Limited exposure may increase the risk of infections, allergies, and asthma.11

immune health pollen exposure
Pollen Exposure

can impact a range of immune functions, particularly in individuals with allergic conditions, increasing susceptibility to respiratory infections.12,13

Immune_health_lifestyle_factors
LIFESTYLE FACTORS
Immune Health inadequate nutrition
Inadequate nutrition

a low quality and imbalanced diet with poor micronutrient intake can lead to dysregulated immune responses, including low-grade chronic inflammation, and increased susceptibility to infections.11,14

Immune Health alcohol consumption and smoking
Excessive alcohol consumption and smoking

can disrupt immune responses, promote inflammation, and increase the risk of infections.15

Immune_health_instrinsic_factors
INTRINSIC FACTORS
Immune Health immature immune system
Immature immune systems

in children strongly contribute to their increased susceptibility to infections and to more severe symptoms.16

Immune Health asthma, chronic obstructive pulmonary disease (COPD), diabetes, and cancer
Underlying health conditions

such as asthma, chronic obstructive pulmonary disease (COPD), diabetes, and cancer are associated with weakened immune defenses and chronic inflammation, increasing the susceptibility to respiratory infections.17

Immune health Immunosenescence
Immunosenescence

age-related decline in immune function — may increase susceptibility to infections, age-related chronic diseases, and certain cancers.18

The Path Forward: Adopting an Immune Health Mindset

Our understanding of immune health has evolved dramatically, revealing its profound influence on lifelong health.

Evidence continues to mount showing that:

Immune Health Balanced immune function reduces infection frequency and severity

Balanced immune function reduces infection frequency and severity

Immune Health Preventative approaches to immune health complement other medical treatments

Preventative approaches to immune health complement other medical treatments

Immune Health Supporting immune function decreases dependence on antibiotics​

Supporting immune function decreases dependence on antibiotics

Recent scientific advances have deepened our understanding of how the immune system develops.
 

By integrating immune health into medical decision-making, we create a foundation where prevention works alongside conventional treatments — establishing a more comprehensive approach to long-term human health.

EXPERT INSIGHT:
What is the Immune Health Mindset?

"To include the immune factor in every health equation and decision in the clinical and research fields, as part of the success balance"

- José Tirán-Saucedo

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References:

1. Ignacio A, et al. Semin Immunol. 2024;73:101885.
2. Tabilas C, et al. Proc Natl Acad Sci USA. 2022;119(49):e2212548119.
3. World Health Organization. Fact sheets: antimicrobial resistance. Available from: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance. Accessed June 2025.
4. Baker RE, et al. Nat Rev Microbiol. 2022;20(4):193-205.
5. Medina M, Castillo-Pino E. Ther Adv Urol. 2019;11:1756287219832172.
6. Mayor S. BMJ. 2010;341:c6360.
7. Sujith S, et al. Front Cell Infect Microbiol. 2024;14:1402941. 
8. EACCI. Global Atlas of Allergy. Available from: https://hub.eaaci.org/education_books/global-atlas-of-allergy/. Accessed June 2025.
9. GBD 2021 Asthma and Allergic Diseases Collaborators. Lancet Respir Med. 2025;13(5):425-46.
10. Loaiza-Ceballos MC, et al. Air Qual Atmos Health. 2022;15(1):105-14.
11. Skevak C, et al. J Allergy Clin Immunol. 2024;153:1194-205.
12. Gilles S, et al. Allergy. 2020;75(3):576-87.
13. Choi YJ, et al. Allergy Asthma Immunol Res. 2022;14(3):289-99.
14. Bajpai G, Nahrendorf M. Immunity. 2021;54(6):1110-22.
15. de Frel DL, et al. Front Nutr. 2020;7:597600.
16. Nunez N, et al. Vaccines. 2021;9:584.
17. Edwards MR, et al. Exacerbations of chronic respiratory diseases. In: Rhinovirus Infections. 2019:137-68.
18. Liu Z, et al. Signal Transduct Target Ther. 2023;8(1):200.